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The practical consequence is that the GHK-Cu complex may partially degrade in the presence of high-concentration ascorbic acid on the skin surface, and the free copper(I) could be mildly pro-oxidant
However, in the non-senescent control fibroblast model cultured in 10% FBS DMEM treated with or without FOXO4-DRI (25 M), no SA--gal-positive cells were observed both in keloid fibroblasts and in normal skin fibroblasts (Supplementary Fig
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